Potent antihepatotoxic activity of dicaffeoyl quinic acids from propolis

Biol Pharm Bull. 1996 Apr;19(4):655-7. doi: 10.1248/bpb.19.655.

Abstract

Hepatoprotective activity guided chemical analyses led to the isolation of two dicaffeoyl quinic acid derivatives, methyl 3,4-di-O-caffeoyl quinate (1) and 3,4-di-O-caffeoyl quinic acid (2) from water extract of propolis, and their structures were determined by the use of 2D NMR. These compounds were stronger antihepatotoxic agents than glycyrrhizin.

MeSH terms

  • Alanine Transaminase / blood
  • Animals
  • Aspartate Aminotransferases / blood
  • Carbon Tetrachloride
  • Cells, Cultured
  • Chemical and Drug Induced Liver Injury
  • Disease Models, Animal
  • Glycyrrhetinic Acid / analogs & derivatives
  • Glycyrrhetinic Acid / pharmacology
  • Glycyrrhizic Acid
  • L-Lactate Dehydrogenase / blood
  • Liver / drug effects*
  • Liver / metabolism
  • Liver Diseases / drug therapy*
  • Liver Diseases / metabolism
  • Magnetic Resonance Spectroscopy
  • Mass Spectrometry
  • Molecular Structure
  • Propolis / chemistry*
  • Propolis / pharmacology*
  • Quinic Acid / analogs & derivatives*
  • Quinic Acid / pharmacology*
  • Rats

Substances

  • Quinic Acid
  • Glycyrrhizic Acid
  • Propolis
  • Carbon Tetrachloride
  • L-Lactate Dehydrogenase
  • Aspartate Aminotransferases
  • Alanine Transaminase
  • Glycyrrhetinic Acid