The CDKN2A (p16) gene and human cancer

Mol Med. 1997 Jan;3(1):5-20.


CDKN2A, the gene encoding the cell-cycle inhibitor p16CDKN2A, was first identified in 1994. Since then, somatic mutations have been observed in many cancers and germline alterations have been found in kindreds with familial atypical multiple mole/melanoma (FAMMM), also known as atypical mole syndrome. In this review we tabulate the known mutations in this gene and discuss specific aspects, particularly with respect to germline mutations and cancer predisposition.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Carrier Proteins / genetics*
  • Cyclin-Dependent Kinase Inhibitor p16
  • Genes, Tumor Suppressor / genetics*
  • Humans
  • Mutation*
  • Neoplasms / genetics*


  • Carrier Proteins
  • Cyclin-Dependent Kinase Inhibitor p16