Randomised, double blind, crossover challenge study of allergenicity of peanut oils in subjects allergic to peanuts

BMJ. 1997 Apr 12;314(7087):1084-8. doi: 10.1136/bmj.314.7087.1084.


Objective: To determine the in vivo allergenicity of two grades of peanut oil for a large group of subjects with proved allergy to peanuts.

Design: Double blind, crossover food challenge with crude peanut oil and refined peanut oil.

Setting: Dedicated clinical investigation unit in a university hospital.

Subjects: 60 subjects allergic to peanuts; allergy was confirmed by challenge tests.

Outcome measures: Allergic reaction to the tested peanut oils.

Results: None of the 60 subjects reacted to the refined oil; six (10%) reacted to the crude oil. Supervised peanut challenge caused considerably less severe reactions than subjects had reported previously.

Conclusions: Crude peanut oil caused allergic reactions in 10% of allergic subjects studied and should continue to be avoided. Refined peanut oil did not pose a risk to any of the subjects. It would be reasonable to recommend a change in labelling to distinguish refined from crude peanut oil.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Arachis / adverse effects*
  • Cross-Over Studies
  • Dietary Fats, Unsaturated / adverse effects
  • Double-Blind Method
  • Female
  • Food Hypersensitivity / diagnosis
  • Food Hypersensitivity / etiology*
  • Food Labeling
  • Humans
  • Male
  • Middle Aged
  • Plant Oils / adverse effects*
  • Plant Oils / chemistry
  • Skin Tests


  • Dietary Fats, Unsaturated
  • Plant Oils