The human growth factor-inducible immediate early gene, CYR61, maps to chromosome 1p

Oncogene. 1997 Apr 10;14(14):1753-7. doi: 10.1038/sj.onc.1200986.


Complementary DNA encoding the human CYR61 protein was isolated from human embryonic tissues and mapped to chromosome 1p22-p31. We show that CYR61 encodes a 381 amino acid protein rich in cysteine and proline residues that is strongly conserved with the mouse homologue. Sequence analysis reveals the presence of several distinct protein domains which confer a mosaic structure to this protein and makes human CYR61 a member of a recently described growth regulator family that includes several proto-oncogene products. From our results we hypothesize that this new immediate early gene may play a role in cell commitment during embryogenesis and more generally in the control of cell proliferation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Base Sequence
  • Chromosome Mapping
  • Chromosomes, Human, Pair 1*
  • Cloning, Molecular
  • Cysteine-Rich Protein 61
  • Gene Expression
  • Growth Substances / genetics*
  • Humans
  • Immediate-Early Proteins / genetics*
  • In Situ Hybridization, Fluorescence
  • Intercellular Signaling Peptides and Proteins*
  • Molecular Sequence Data
  • RNA, Messenger / genetics
  • Sequence Alignment
  • Sequence Homology, Amino Acid


  • CCN1 protein, human
  • CCN1 protein, mouse
  • Cysteine-Rich Protein 61
  • Growth Substances
  • Immediate-Early Proteins
  • Intercellular Signaling Peptides and Proteins
  • RNA, Messenger

Associated data

  • GENBANK/U62015