Cyclophosphamide in severe steroid-resistant bronchiolitis obliterans organizing pneumonia

Respir Med. 1997 Mar;91(3):175-7. doi: 10.1016/s0954-6111(97)90055-x.


A patient receiving carbamazepine and imipramine presented with severe bronchiolitis obliterans organizing pneumonia (BOOP). He developed progressive respiratory failure in spite of high-dose steroid treatment. Cyclophosphamide was given as adjunctive therapy, and a rapid improvement was seen. The authors suggest that an early therapeutic trial of cyclophosphamide should be considered in patients with BOOP who fail to respond to steroids.

Publication types

  • Case Reports

MeSH terms

  • Anti-Inflammatory Agents / therapeutic use*
  • Chemotherapy, Adjuvant
  • Cryptogenic Organizing Pneumonia / drug therapy*
  • Cyclophosphamide / therapeutic use*
  • Drug Resistance
  • Drug Therapy, Combination
  • Humans
  • Male
  • Middle Aged
  • Prednisolone / therapeutic use*


  • Anti-Inflammatory Agents
  • Cyclophosphamide
  • Prednisolone