Dynamic organisation of intermediate filaments and associated proteins during the cell cycle

Bioessays. 1997 Apr;19(4):297-305. doi: 10.1002/bies.950190407.

Abstract

Intermediate filaments, which form the structural framework of both the cytoskeleton and the nuclear lamina in most eukaryotic cells, have been found to be highly dynamic structures. A continuous exchange of subunit proteins at the filament surface and a stabilisation of soluble subunits by chaperone-type proteins may modulate filament structure and plasticity. Recent studies on the cell cycle-dependent interaction of intermediate filaments with associated proteins, and a detailed analysis of intermediate filament phosphorylation in defined subcellular locations at various stages of mitosis, have brought new insights into the molecular mechanisms involved in the mitotic reorganisation of intermediate filaments. Some of these studies have allowed new speculations about the possible cellular functions of cytoplasmic intermediate filaments, and increased our understanding of the specific functions of the lamins and the lamina-associated membrane proteins in the post-mitotic reassembly of the nucleus.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Cycle*
  • Cytoskeleton / metabolism
  • Cytoskeleton / ultrastructure
  • Eukaryotic Cells / cytology
  • Eukaryotic Cells / metabolism
  • Intermediate Filament Proteins / metabolism*
  • Intermediate Filaments / metabolism*
  • Intermediate Filaments / ultrastructure
  • Lamins
  • Membrane Proteins / physiology
  • Mitosis
  • Models, Biological
  • Nuclear Proteins / metabolism
  • Nuclear Proteins / physiology
  • Phosphorylation
  • Protein Prenylation
  • Protein Processing, Post-Translational

Substances

  • Intermediate Filament Proteins
  • Lamins
  • Membrane Proteins
  • Nuclear Proteins