Hepatic resection for hepatocellular carcinoma

Am J Surg. 1997 Apr;173(4):288-91. doi: 10.1016/S0002-9610(96)00399-6.


Background: The significance of pTNM staging of hepatocellular carcinoma (HCC) as a prognostic factor after hepatic resection was evaluated.

Patients and methods: The prognoses were analyzed in 262 patients treated with hepatic resection for HCC.

Results: As a whole, the pTNM stages correlated well with the survival rates. The survival rates of stage I and II patients were significantly higher than those of stages III and IV. However, there was no significant difference in survivals between stage I and II, and between stage III and IV-A. The survival rates of the patients treated with segmentectomy or lobectomy in stages I and II were significantly higher than those with subsegmentectomy or smaller resection. Multivariate analysis revealed that tumor size greater than 2 cm, multiple gross tumors, surgical margin less than 1 cm, and Child C classification were independently significant factors of poor survival.

Conclusions: The results of hepatic resection for HCC should be stratified by pTNM staging and by Child classification of hepatic function before comparison.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Carcinoma, Hepatocellular / mortality
  • Carcinoma, Hepatocellular / pathology
  • Carcinoma, Hepatocellular / surgery*
  • Female
  • Hepatectomy*
  • Humans
  • Liver Neoplasms / mortality
  • Liver Neoplasms / pathology
  • Liver Neoplasms / surgery*
  • Male
  • Middle Aged
  • Neoplasm Recurrence, Local
  • Neoplasm Staging
  • Prognosis
  • Proportional Hazards Models
  • Survival Rate