Biological characteristics of adrenocortical carcinoma: a study of p53, IGF, EGF-r, Ki-67 and PCNA in 17 adrenocortical carcinomas

Anticancer Res. 1997 Mar-Apr;17(2B):1303-9.


Adrenocortical carcinoma (ACC) is a rare neoplasm with a poor prognosis. Prognostic factors are needed to identify patients who should be treated aggressively and those for which a less aggressive approach is warranted. As a result of advances within the field of immunohistochemistry, investigations of Ki-67, PCNA, IGF, EGF-r and p53 were performed in 17 ACC. The aim of this study was to clarify the role of Ki-67, PCNA, EGF-r, IGF and p53 in correlation to tumour behaviour and outcome. This retrospective study includes 16 patients, 10 women and 6 men, with a median age of 46 years. Nine tumours were hormonally functioning and 7 were non-functioning. The results obtained revealed that all tumours expressed PCNA and Ki-67 with median values of 59% and 14%, respectively, while p53 was negative in 88%, IGF negative in 82% and EGF-r positive in 94% of the tumours. No correlation was found between p53, IGF, EGF-r and survival rate. There was no interdependence between PCNA and Ki-67, or between PCNA, Ki-67 and the survival rate.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adrenal Cortex Neoplasms / chemistry*
  • Adrenal Cortex Neoplasms / mortality
  • Adult
  • Aged
  • ErbB Receptors / analysis*
  • Female
  • Humans
  • Ki-67 Antigen / analysis*
  • Male
  • Middle Aged
  • Proliferating Cell Nuclear Antigen / analysis*
  • Retrospective Studies
  • Somatomedins / analysis*
  • Survival Rate
  • Tumor Suppressor Protein p53 / analysis*


  • Ki-67 Antigen
  • Proliferating Cell Nuclear Antigen
  • Somatomedins
  • Tumor Suppressor Protein p53
  • ErbB Receptors