Prophylactic treatment of migraine with gamma-linolenic and alpha-linolenic acids

Cephalalgia. 1997 Apr;17(2):127-30; discussion 102. doi: 10.1046/j.1468-2982.1997.1702127.x.


Polyunsaturated fatty acids (PUFA) were administered to 168 patients over a period of 6 months in an open-label uncontrolled study. In 129 patients available for study, 86% experienced reduction in severity, frequency and duration of migraine attacks, 22% became free of migraine and more than 90% had reduced nausea and vomiting. Self-medication changed to simple analgesics in the majority except in 14% of patients without improvement.

Publication types

  • Clinical Trial

MeSH terms

  • Adult
  • Female
  • Humans
  • Male
  • Migraine Disorders / drug therapy*
  • Migraine Disorders / prevention & control
  • alpha-Linolenic Acid / therapeutic use*
  • gamma-Linolenic Acid / therapeutic use*


  • alpha-Linolenic Acid
  • gamma-Linolenic Acid