[Ability of carbon dioxide to inhibit generation of superoxide anion radical in cells and its biomedical role]

Vopr Med Khim. Jul-Sep 1996;42(3):193-202.
[Article in Russian]

Abstract

The study was carried out on blood phagocytes and alveolar macrophages of 96 persons, cells of inner organs and tissue phagocytes (liver, brain, myocardium, lungs, kidneys, stomach, skeletal muscles), as well as on mitochondria of the liver of 186 non-linear white mice. Generation of active oxygen forms (AOF) was evaluated by various methods with CO2 directly affecting the cells and bioptates and indirectly the whole organism. The results show that CO2 with tension close to that of the blood (37.0 mm Hg) and at higher tensions (60 and 146 mm Hg) is a powerful inhibitor of AOF generation by human and animal cells, as well as by liver mitochondria of mice. The data obtained allow to explain, in terms of AOF role, a number of physiological and pathophysiological (medical) CO2 effects.

Publication types

  • English Abstract

MeSH terms

  • Animals
  • Carbon Dioxide / pharmacology*
  • Humans
  • Indicators and Reagents
  • Luminescent Measurements
  • Luminol
  • Macrophages, Alveolar / drug effects
  • Mice
  • Mitochondria, Liver / drug effects
  • Neutrophils / drug effects
  • Nitroblue Tetrazolium
  • Oxidation-Reduction
  • Oxidative Phosphorylation
  • Phagocytes / drug effects*
  • Phagocytes / metabolism
  • Reactive Oxygen Species / metabolism*
  • Superoxides / metabolism*

Substances

  • Indicators and Reagents
  • Reactive Oxygen Species
  • Superoxides
  • Carbon Dioxide
  • Nitroblue Tetrazolium
  • Luminol