Interaction of the DF3/MUC1 breast carcinoma-associated antigen and beta-catenin in cell adhesion

J Biol Chem. 1997 May 9;272(19):12492-4. doi: 10.1074/jbc.272.19.12492.


The DF3/MUC1 mucin-like glycoprotein is aberrantly overexpressed in human breast carcinomas. The functional role of DF3 is unknown. The present studies demonstrate that DF3 associates with beta-catenin. Similar findings have been obtained for gamma-catenin but not alpha-catenin. DF3, like E-cadherin and the adenomatous polyposis coli gene product, contains an SXXXXXSSL site that is responsible for direct binding to beta-catenin. The results further demonstrate that interaction of DF3 and beta-catenin is dependent on cell adhesion. These findings and the role of beta-catenin in cell signaling support a role for DF3 in the adhesion of epithelial cells.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Adenomatous Polyposis Coli Protein
  • Antigens, Neoplasm / metabolism*
  • Biomarkers, Tumor / metabolism*
  • Breast Neoplasms / metabolism*
  • Cadherins / metabolism*
  • Cell Adhesion
  • Cytoskeletal Proteins / metabolism*
  • Female
  • Genes, APC
  • Humans
  • Mucin-1 / metabolism*
  • Trans-Activators*
  • beta Catenin


  • Adenomatous Polyposis Coli Protein
  • Antigens, Neoplasm
  • Biomarkers, Tumor
  • CTNNB1 protein, human
  • Cadherins
  • Cytoskeletal Proteins
  • Mucin-1
  • Trans-Activators
  • beta Catenin