Role for N-CoR and Histone Deacetylase in Sin3-mediated Transcriptional Repression

Nature. 1997 May 1;387(6628):49-55. doi: 10.1038/387049a0.

Abstract

Normal mammalian growth and development are highly dependent on the regulation of the expression and activity of the Myc family of transcription factors. Mxi1-mediated inhibition of Myc activities requires interaction with mammalian Sin3A or Sin3B proteins, which have been purported to act as scaffolds for additional co-repressor factors. The identification of two such Sin3-associated factors, the nuclear receptor co-repressor (N-CoR) and histone deacetylase (HD1), provides a basis for Mxi1/Sin3-induced transcriptional repression and tumour suppression.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • 3T3 Cells
  • Animals
  • Basic Helix-Loop-Helix Transcription Factors
  • DNA-Binding Proteins / physiology
  • Fungal Proteins / physiology
  • Gene Expression Regulation*
  • Genes, myc
  • Histone Deacetylases / physiology*
  • Humans
  • Mice
  • Nuclear Proteins / physiology*
  • Nuclear Receptor Co-Repressor 1
  • Recombinant Fusion Proteins / genetics
  • Recombinant Fusion Proteins / metabolism
  • Repressor Proteins / physiology*
  • Saccharomyces cerevisiae / genetics
  • Saccharomyces cerevisiae Proteins*
  • Transcription Factors / physiology*
  • Transcription, Genetic
  • Tumor Suppressor Proteins

Substances

  • Basic Helix-Loop-Helix Transcription Factors
  • DNA-Binding Proteins
  • Fungal Proteins
  • MXI1 protein, human
  • Mxi1 protein, mouse
  • NCOR1 protein, human
  • Ncor1 protein, mouse
  • Nuclear Proteins
  • Nuclear Receptor Co-Repressor 1
  • PAH2 protein, Pichia angusta
  • Recombinant Fusion Proteins
  • Repressor Proteins
  • SIN3 protein, S cerevisiae
  • Saccharomyces cerevisiae Proteins
  • Transcription Factors
  • Tumor Suppressor Proteins
  • Histone Deacetylases