Variation in placental type 2 11beta-hydroxysteroid dehydrogenase activity is not related to birth weight or placental weight

Mol Cell Endocrinol. 1997 Apr 4;128(1-2):103-9. doi: 10.1016/s0303-7207(97)04027-6.

Abstract

It has been suggested that the association between the development of hypertension and a combination of low birth weight and high placental weight can be explained by variations in expression of NAD+-dependent 11beta-hydroxysteroid dehydrogenase (11-HSD2 or 11-HSD K) in the placenta. Enzymatic activity and mRNA levels of 11-HSD2 were measured in 111 human placentas taken from normal births. There were no correlations between either 11-HSD2 activity or mRNA levels and either fetal or placental weight. These studies suggest that variations in placental 11-HSD activity do not influence fetal or placental weight in humans.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • 11-beta-Hydroxysteroid Dehydrogenases
  • Adolescent
  • Adult
  • Birth Weight*
  • Choriocarcinoma
  • Cortisone / metabolism
  • Female
  • Humans
  • Hydroxysteroid Dehydrogenases / biosynthesis
  • Hydroxysteroid Dehydrogenases / metabolism*
  • Infant, Low Birth Weight
  • Infant, Newborn
  • Isoenzymes / biosynthesis
  • Isoenzymes / metabolism*
  • Organ Size
  • Placenta / anatomy & histology*
  • Placenta / enzymology*
  • Pregnancy
  • RNA, Messenger / metabolism
  • Recombinant Proteins / biosynthesis
  • Recombinant Proteins / metabolism
  • Reference Values
  • Risk Factors
  • Transfection
  • Tumor Cells, Cultured
  • Uterine Neoplasms

Substances

  • Isoenzymes
  • RNA, Messenger
  • Recombinant Proteins
  • Hydroxysteroid Dehydrogenases
  • 11-beta-Hydroxysteroid Dehydrogenases
  • Cortisone