Is CD46 the cellular receptor for measles virus?

Virus Res. 1997 Apr;48(1):1-9. doi: 10.1016/s0168-1702(96)01421-9.

Abstract

Although CD46 would appear to be the cellular receptor for vaccine strains of measles virus (MV), recently there has been an accumulation of data suggesting that CD46 does not play this role for MV wild-type strains. Clarification of the nature of the MV receptor is necessary for the development of more effective vaccines against this virus which is responsible for the deaths of nearly two million children each year in the Third World.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antigens, CD / metabolism*
  • Hemagglutination Tests
  • Humans
  • Measles Vaccine / metabolism
  • Measles virus / metabolism*
  • Membrane Cofactor Protein
  • Membrane Glycoproteins / metabolism*
  • Receptors, Virus / metabolism*
  • Vaccines, Attenuated / metabolism
  • Viral Proteins / metabolism

Substances

  • Antigens, CD
  • CD46 protein, human
  • Measles Vaccine
  • Membrane Cofactor Protein
  • Membrane Glycoproteins
  • Receptors, Virus
  • Vaccines, Attenuated
  • Viral Proteins