The progressive tactile hyperalgesia induced by peripheral inflammation is nerve growth factor dependent

Neuroreport. 1997 Mar 3;8(4):807-10. doi: 10.1097/00001756-199703030-00001.


Experimental peripheral inflammation results in cutaneous mechanical hypersensitivity, and repeated low intensity mechanical stimulation of the inflamed skin induces a progressively incrementing hyperalgesia. We have now examined whether the elevation in nerve growth factor (NGF) induced by the inflammation contributes to this progressive hyperalgesia. An i.p. injection of anti-NGF antiserum (5 microliters g-1) 1 h before induction of inflammation by intraplantar complete Freund's adjuvant (CFA) injection and 24 h after, both reduced the basal inflammatory hypersensitivity and significantly attenuated the progressive increase of spontaneous activity, touch-, pinch- and A beta-afferent-evoked responses, and the progressive reduction of the mechanical threshold of biceps femoris/semitendinosus alpha motoneurones normally evoked by repeated (every 5 min) tactile stimulation of the inflamed hindpaw, in decerebrate-spinal rats. NGF contributes, therefore, to the progressive tactile hyperalgesia elicited by repeated touch stimulation of inflamed tissue.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Afferent Pathways / physiology*
  • Analysis of Variance
  • Animals
  • Evoked Potentials
  • Freund's Adjuvant
  • Hyperalgesia / physiopathology*
  • Immune Sera
  • Inflammation / physiopathology*
  • Male
  • Motor Neurons / physiology
  • Muscle, Skeletal / innervation
  • Nerve Growth Factors / immunology
  • Nerve Growth Factors / physiology*
  • Pain / physiopathology
  • Physical Stimulation
  • Rats
  • Rats, Sprague-Dawley
  • Touch


  • Immune Sera
  • Nerve Growth Factors
  • Freund's Adjuvant