Abstract
Phosphorus 31 magnetic resonance spectroscopy at 2 T was used to monitor high-energy phosphate metabolism over a 3-week period in a canine model of myocardial infarction and reperfusion. Twenty animals were divided into two groups: group 1 (n = 11) received intravenous nitroglycerin beginning at the onset of coronary occlusion; group 2 (n = 9) received a 105-minute infusion of superoxide dismutase (SOD) beginning at the onset of reperfusion. A metabolic protective effect was observed (vs controls) with both agents, manifested by a reduction in the degree of pH decline from baseline values and preservation of the adenosine triphosphate/total phosphate ratio during occlusion and reperfusion. Further, both treatments, compared with controls, produced a lower infarct/zone at risk ratio: controls, 1.5 +/- 1.2; nitroglycerin, 0.52 +/- 0.50; and SOD, 0.64 +/- 0.40. The technique of 31P magnetic resonance spectroscopy demonstrated its use for the noninvasive assessment of myocardial metabolism in response to therapeutic intervention.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Adenosine Triphosphate / metabolism
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Animals
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Contrast Media
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Dogs
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Female
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Free Radical Scavengers / administration & dosage
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Free Radical Scavengers / therapeutic use*
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Gadolinium DTPA
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Hydrogen-Ion Concentration
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Infusions, Intravenous
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Magnetic Resonance Spectroscopy / methods
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Myocardial Reperfusion / methods*
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Myocardial Reperfusion Injury / diagnosis*
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Myocardial Reperfusion Injury / metabolism
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Myocardial Reperfusion Injury / prevention & control*
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Myocardium / metabolism*
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Nitroglycerin / administration & dosage
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Nitroglycerin / therapeutic use*
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Organometallic Compounds
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Pentetic Acid / analogs & derivatives
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Phosphates / metabolism
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Phosphocreatine / metabolism
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Superoxide Dismutase / administration & dosage
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Superoxide Dismutase / therapeutic use*
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Vasodilator Agents / administration & dosage
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Vasodilator Agents / therapeutic use*
Substances
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Contrast Media
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Free Radical Scavengers
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Organometallic Compounds
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Phosphates
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Vasodilator Agents
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Phosphocreatine
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Pentetic Acid
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Adenosine Triphosphate
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Superoxide Dismutase
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Nitroglycerin
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Gadolinium DTPA