A novel putative G-protein-coupled receptor expressed in lung, heart and lymphoid tissue

FEBS Lett. 1997 Apr 21;407(1):59-62. doi: 10.1016/s0014-5793(97)00278-0.


cDNA encoding a novel putative G-protein-coupled receptor, named LyGPR (lymphocyte derived G-protein-coupled receptor) was cloned using a reverse transcription-PCR approach. The LyGPR amino acid sequence is 375 residues long and shows similarity (about 30-35% identity) both to the angiotensin receptors and members of the chemokine receptor family. Northern blot analysis revealed a 3.1-kb LyGPR transcript expressed predominantly in lung, heart and lymphoid tissues. LyGPR expression was also detected in the pre-B acute lymphoblastoid leukemia cell lines Reh and Nalm-6, in the Burkitt's lymphoma line Daudi, and in hematopoietic progenitor cells from bone marrow, as well as in B cells, T cells and monocytes from peripheral blood.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Cloning, Molecular
  • DNA, Complementary / genetics
  • GTP-Binding Proteins / metabolism
  • Humans
  • Lung / chemistry*
  • Lymphoid Tissue / chemistry*
  • Molecular Sequence Data
  • Myocardium / chemistry*
  • Polymerase Chain Reaction
  • Receptors, Cell Surface / analysis*
  • Receptors, Cell Surface / genetics
  • Sequence Analysis, DNA
  • Sequence Homology, Amino Acid
  • Signal Transduction
  • Tissue Distribution


  • DNA, Complementary
  • Receptors, Cell Surface
  • GTP-Binding Proteins

Associated data

  • GENBANK/X98510