HIV infection induces changes in CD4+ T-cell phenotype and depletions within the CD4+ T-cell repertoire that are not immediately restored by antiviral or immune-based therapies

Nat Med. 1997 May;3(5):533-40. doi: 10.1038/nm0597-533.


Changes in CD4+ T-cell surface marker phenotype and antigen receptor (TCR) repertoire were examined during the course of HIV infection and following therapy. A preferential decline in naive CD4+ T cells was noted as disease progressed. Following protease inhibitor therapy, naive CD4+ T cells increased only if they were present before initiation of therapy. Disruptions of the CD4+ TCR repertoire were most prevalent in patients with the lowest CD4+ T-cell counts. Antiviral or IL-12 therapy-induced increases in CD4+ T-cell counts led to only minor changes in previously disrupted repertoires. Thus, CD4+ T-cell death mediated by HIV-1 infection may result in a preferential decline in the number of naive CD4+ T cells and disruptions of the CD4+ T-cell repertoire that are not immediately corrected by antiviral or immune-based therapies.

MeSH terms

  • CD4-Positive T-Lymphocytes / immunology*
  • Disease Progression
  • HIV Infections / drug therapy
  • HIV Infections / immunology*
  • HIV Protease Inhibitors / therapeutic use*
  • Humans
  • Indinavir / therapeutic use*
  • Interleukin-2 / therapeutic use*
  • Leukocyte Common Antigens / blood
  • Phenotype
  • RNA, Messenger / blood
  • Receptors, Antigen, T-Cell, alpha-beta / genetics
  • Twins, Monozygotic


  • HIV Protease Inhibitors
  • Interleukin-2
  • RNA, Messenger
  • Receptors, Antigen, T-Cell, alpha-beta
  • Indinavir
  • Leukocyte Common Antigens