Some quantitative uses of drug antagonists. 1958

Br J Pharmacol. 1997 Feb;120(4 Suppl):151-61; discussion 148-50. doi: 10.1111/j.1476-5381.1997.tb06793.x.

Abstract

Various applications of pAx measurements are discussed based on the hypothesis that drugs and drug antagonists compete for receptors according to the mass law. Examples are given illustrating the use of pAx measurements to identify agonists which act on the same receptors and to compare the receptors of different tissues. Tests of competitive and noncompetitive antagonism are considered in relation to the antagonisms acetylcholine-atropine, histamine-atropine and acetylcholine-cinchonidine. A new measure, pAh, is introduced to express the activity of unsurmountable antagonists.

Publication types

  • Biography
  • Classical Article
  • Historical Article

MeSH terms

  • Acetylcholine / history
  • Acetylcholine / metabolism
  • Acetylcholine / pharmacology
  • Animals
  • Atropine / history
  • Atropine / pharmacology
  • Binding, Competitive
  • Drug Antagonism*
  • Guinea Pigs
  • Histamine / history
  • Histamine / metabolism
  • Histamine / pharmacology
  • Histamine Agonists / history*
  • Histamine Agonists / metabolism
  • Histamine Agonists / pharmacology
  • History, 20th Century
  • Models, Chemical
  • Muscarinic Antagonists / history*
  • Muscarinic Antagonists / metabolism
  • Muscarinic Antagonists / pharmacology
  • Muscle, Smooth / drug effects*
  • Muscle, Smooth / metabolism
  • Receptors, Drug / history
  • Receptors, Drug / metabolism

Substances

  • Histamine Agonists
  • Muscarinic Antagonists
  • Receptors, Drug
  • Atropine
  • Histamine
  • Acetylcholine

Personal name as subject

  • O Arunlakshana
  • H O Schild