Clinical evaluation of technetium-99m infecton for the localisation of bacterial infection

Eur J Nucl Med. 1997 May;24(5):553-6. doi: 10.1007/BF01267688.


The aim of the study was to distinguish infection from inflammation in patients with suspected infection using technetium-99m Infecton. Ninety-nine patients (102 studies) referred for infection evaluation underwent imaging with 400 MBq 99mTc-Infecton at 1 and 4 h. Most patients had appropriate microbiological tests and about half (56) had radiolabelled white cell scans as well. No adverse effects were noted in any patient. The clinical efficacy of 99mTc-Infecton depended in part on whether imaging was undertaken during antibiotic therapy for infection or not. In consultation with the microbiologist, 5-14 days of appropriate and successful antibiotic therapy was considered adequate to classify some results as true-negatives. The figures for sensitivity and specificity of 99mTc-Infecton for active or unsuccessfully treated infection were 83% and 91% respectively. It is concluded that 99mTc-Infecton imaging contributed to the differential diagnosis of inflammation. It is being used as the first imaging modality when bacterial infection is suspected.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Anti-Infective Agents* / therapeutic use
  • Bacterial Infections / diagnostic imaging*
  • Ciprofloxacin* / therapeutic use
  • Diagnosis, Differential
  • Female
  • Humans
  • Inflammation / diagnosis
  • Leukocytes
  • Male
  • Middle Aged
  • Radionuclide Imaging
  • Sensitivity and Specificity
  • Technetium*


  • Anti-Infective Agents
  • Ciprofloxacin
  • Technetium