Neutralizing antiviral B cell responses

Annu Rev Immunol. 1997;15:235-70. doi: 10.1146/annurev.immunol.15.1.235.


Neutralizing antiviral B cell responses differ in various aspects from the many usually measured B cell responses specific for protein in adjuvants. In particular, such neutralizing antiviral B cell responses are more rapidly induced, reach higher titers, are longer lived, and are efficiently generated without adjuvants. Evidence is summarized here that the repetitiveness of many viral antigens is a key factor responsible for the efficiency of these B cell responses, amplifying B cells early and rapidly for potent IgM responses and also for efficient switching to IgG. The data reviewed indicate that B cells discriminate antigen patterns via the degree of surface Ig-cross-linking and use antigen repetitiveness as a self/nonself discriminator.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antibodies, Viral / biosynthesis*
  • Antigens, Viral
  • B-Lymphocytes / immunology*
  • Humans
  • Immunologic Memory
  • Lymphocyte Activation
  • Lymphocyte Cooperation
  • Membrane Glycoproteins*
  • Models, Biological
  • Neutralization Tests
  • Signal Transduction
  • T-Lymphocytes / immunology
  • Vesicular stomatitis Indiana virus / immunology
  • Viral Envelope Proteins / immunology
  • Virus Diseases / immunology


  • Antibodies, Viral
  • Antigens, Viral
  • G protein, vesicular stomatitis virus
  • Membrane Glycoproteins
  • Viral Envelope Proteins