Initiation and processing of signals from the B cell antigen receptor

Annu Rev Immunol. 1997;15:453-79. doi: 10.1146/annurev.immunol.15.1.453.

Abstract

Current models of signal transduction from the antigen receptors on B and T cells still resemble equations with several unknown elements. Data from recent knockout experiments in cell lines and mice contradict the assumption that Src-family kinase and tyrosine kinases of the Syk/Zap-70 family are the transducer elements that set signaling from these receptors in motion. Using a functional definition of signaling elements, we discuss the current knowledge of signaling events from the BCR and suggest the existence of an as-yet-unknown BCR transducer complex.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Biological Evolution
  • Humans
  • Mice
  • Models, Biological
  • Protein Tyrosine Phosphatases / metabolism
  • Protein-Tyrosine Kinases / metabolism
  • Receptors, Antigen, B-Cell / metabolism*
  • Signal Transduction

Substances

  • Receptors, Antigen, B-Cell
  • Protein-Tyrosine Kinases
  • Protein Tyrosine Phosphatases