(RS)-2-chloro-5-hydroxyphenylglycine (CHPG) activates mGlu5, but no mGlu1, receptors expressed in CHO cells and potentiates NMDA responses in the hippocampus

Neuropharmacology. 1997 Feb;36(2):265-7. doi: 10.1016/s0028-3908(97)00001-4.


A new phenylglycine derivative, (RS)-2-chloro-5-hydroxyphenylglycine (CHPG), has been synthesized and shown to selectively activate mGlu5a receptors, compared to mGlu1 alpha receptors, when expressed in CHO cells. This selective mGlu5 receptor agonist also potentiates NMDA-induced depolarizations in rat hippocampal slices. CHPG may be a useful tool for studying the role of mGlu5 receptors in the central nervous system.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • CHO Cells
  • Calcium / metabolism
  • Cricetinae
  • Excitatory Amino Acid Agonists / pharmacology*
  • Glycine / analogs & derivatives*
  • Glycine / pharmacology
  • Hippocampus / drug effects
  • Hippocampus / metabolism*
  • In Vitro Techniques
  • N-Methylaspartate / pharmacology*
  • Phenylacetates / pharmacology*
  • Rats
  • Receptors, Metabotropic Glutamate / drug effects*


  • 2-chloro-5-hydroxyphenylglycine
  • Excitatory Amino Acid Agonists
  • Phenylacetates
  • Receptors, Metabotropic Glutamate
  • N-Methylaspartate
  • Calcium
  • Glycine