Abstract
Himachalol (a sesquiterpene alcohol) showed low in vitro minimum inhibitory concentrations against Aspergillus fumigatus by the macro- and microbroth dilution techniques (genometric mean 250 micrograms ml-1 and 46.4 micrograms ml-1 respectively) compared with saperconazole. Swiss mice treated with the phytoproduct (200 mg kg-1, p.o.) once daily for 7 days exhibited a significant (P < 0.001) protection (60%) together with an increase in the mean survival time (15 days) and a reduced CFU (mean log10) burden of A. fumigatus in the kidneys.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antifungal Agents / pharmacology
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Antifungal Agents / therapeutic use*
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Aspergillosis / drug therapy*
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Aspergillus fumigatus* / drug effects
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Aspergillus fumigatus* / isolation & purification
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Azoles / pharmacology
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Benzocycloheptenes / pharmacology
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Benzocycloheptenes / therapeutic use*
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Humans
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Male
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Mice
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Microbial Sensitivity Tests
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Polycyclic Sesquiterpenes
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Sesquiterpenes / pharmacology
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Sesquiterpenes / therapeutic use*
Substances
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Antifungal Agents
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Azoles
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Benzocycloheptenes
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Polycyclic Sesquiterpenes
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Sesquiterpenes
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himachalol
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saperconazole