Evaluation of himachalol in murine invasive aspergillosis

Mycoses. 1996 Nov-Dec;39(11-12):449-52. doi: 10.1111/j.1439-0507.1996.tb00095.x.

Abstract

Himachalol (a sesquiterpene alcohol) showed low in vitro minimum inhibitory concentrations against Aspergillus fumigatus by the macro- and microbroth dilution techniques (genometric mean 250 micrograms ml-1 and 46.4 micrograms ml-1 respectively) compared with saperconazole. Swiss mice treated with the phytoproduct (200 mg kg-1, p.o.) once daily for 7 days exhibited a significant (P < 0.001) protection (60%) together with an increase in the mean survival time (15 days) and a reduced CFU (mean log10) burden of A. fumigatus in the kidneys.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antifungal Agents / pharmacology
  • Antifungal Agents / therapeutic use*
  • Aspergillosis / drug therapy*
  • Aspergillus fumigatus* / drug effects
  • Aspergillus fumigatus* / isolation & purification
  • Azoles / pharmacology
  • Benzocycloheptenes / pharmacology
  • Benzocycloheptenes / therapeutic use*
  • Humans
  • Male
  • Mice
  • Microbial Sensitivity Tests
  • Polycyclic Sesquiterpenes
  • Sesquiterpenes / pharmacology
  • Sesquiterpenes / therapeutic use*

Substances

  • Antifungal Agents
  • Azoles
  • Benzocycloheptenes
  • Polycyclic Sesquiterpenes
  • Sesquiterpenes
  • himachalol
  • saperconazole