Specific protein recognition of an mRNA cap through its alkylated base

Nat Struct Biol. 1997 May;4(5):350-4. doi: 10.1038/nsb0597-350.


The specific binding of N7-methylguanine cap analogues to the RNA methyltransferase VP39 was observed through X-ray crystallography, providing a prototypical structure for a complex between a protein and an mRNA 5' cap.

Publication types

  • Letter

MeSH terms

  • Alkylation
  • Binding Sites
  • Crystallography, X-Ray
  • Methyltransferases / chemistry*
  • RNA Cap Analogs / chemistry
  • Viral Proteins / chemistry*


  • RNA Cap Analogs
  • VP39 protein, Vaccinia virus
  • Viral Proteins
  • Methyltransferases
  • RNA 2'-O-methyltransferase

Associated data

  • PDB/1P39
  • PDB/1V39
  • PDB/1VP3
  • PDB/1VP9
  • PDB/2VP3