Extraction and purification of effective antimicrobial constituents of Terminalia chebula RETS. against methicillin-resistant Staphylococcus aureus

Y Sato; H Oketani; K Singyouchi; T Ohtsubo; M Kihara; H Shibata; T Higuti

doi:10.1248/bpb.20.401

Extraction and purification of effective antimicrobial constituents of Terminalia chebula RETS. against methicillin-resistant Staphylococcus aureus

Biol Pharm Bull. 1997 Apr;20(4):401-4. doi: 10.1248/bpb.20.401.

Authors

Y Sato¹, H Oketani, K Singyouchi, T Ohtsubo, M Kihara, H Shibata, T Higuti

Affiliation

¹ Faculty of Pharmaceutical Sciences, University of Tokushima, Japan.

PMID: 9145218
DOI: 10.1248/bpb.20.401

Abstract

Examination of the EtOH extract of the fruiting bodies of Terminalia chebula RETZ. led to the isolation of two potent antimicrobial substances against even methicillin-resistant strains of Staphylococcus aureus. On the basis of spectroscopic evidence, the two isolates have been identified as gallic acid and its ethyl ester.

MeSH terms

Anti-Bacterial Agents / isolation & purification
Anti-Bacterial Agents / pharmacology*
Gallic Acid / analogs & derivatives
Gallic Acid / isolation & purification
Gallic Acid / pharmacology
Methicillin Resistance
Microbial Sensitivity Tests
Plant Extracts / chemistry
Plant Extracts / pharmacology
Plants, Medicinal / chemistry*
Staphylococcus aureus / drug effects*

Substances

Anti-Bacterial Agents
Plant Extracts
ethyl gallate
Gallic Acid