Inhibitory effects of quassinoid derivatives on Epstein-Barr virus early antigen activation

S Rahman; N Fukamiya; N Ohno; H Tokuda; H Nishino; K Tagahara; K H Lee; M Okano

doi:10.1248/cpb.45.675

Inhibitory effects of quassinoid derivatives on Epstein-Barr virus early antigen activation

Chem Pharm Bull (Tokyo). 1997 Apr;45(4):675-7. doi: 10.1248/cpb.45.675.

Authors

S Rahman¹, N Fukamiya, N Ohno, H Tokuda, H Nishino, K Tagahara, K H Lee, M Okano

Affiliation

¹ Department of Interdisciplinary Studies on Natural Environment, Faculty of Integrated Arts and Sciences, Hiroshima University, Higashi-Hiroshima, Japan.

PMID: 9145503
DOI: 10.1248/cpb.45.675

Abstract

Short-term in vitro assays for tumor promoters and antitumor promoters (Epstein-Barr virus activation test) were carried out for semisynthetic quassinoids (3-7), which were obtained by esterification of the C-15 OH group of deacetylated isobrucein-B (2). All the ester derivatives showed higher antitumor promoting activity than that of the potent compound 2. A compound containing a fluorinated aliphatic ester showed the highest potency.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antigens, Viral / drug effects*
Antigens, Viral / immunology
Antineoplastic Agents, Phytogenic / chemistry*
Antineoplastic Agents, Phytogenic / pharmacology
Antiviral Agents / chemistry
Antiviral Agents / pharmacology
Glaucarubin / analogs & derivatives*
Glaucarubin / chemistry
Glaucarubin / pharmacology
Herpesvirus 4, Human
Quassins*
Tumor Cells, Cultured
Virus Activation / drug effects

Substances

Antigens, Viral
Antineoplastic Agents, Phytogenic
Antiviral Agents
Epstein-Barr virus early antigen
Quassins
isobrucein B
Glaucarubin