Abstract
A series of diesters of arylnaphthalene lignan and their heteroaromatic analogs were synthesized and evaluated for hypolipidemic activity. The disasters with modifications at C-3 showed excellent hypocholesterolemic and high-density lipoprotein (HDL) cholesterol-elevating activities. Structure-activity analysis indicated that the 2-pyridylmethyl ester 5l has the optimum activity.
MeSH terms
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Animals
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Cholesterol / blood
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Cholesterol, HDL / blood
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Hypolipidemic Agents / chemical synthesis*
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Hypolipidemic Agents / chemistry
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Hypolipidemic Agents / pharmacology
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Lignans / chemical synthesis*
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Lignans / chemistry
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Lignans / pharmacology
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Lipids / blood*
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Male
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Naphthalenes / chemical synthesis*
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Naphthalenes / chemistry
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Naphthalenes / pharmacology
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Rats
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Rats, Sprague-Dawley
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Structure-Activity Relationship
Substances
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Cholesterol, HDL
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Hypolipidemic Agents
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Lignans
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Lipids
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Naphthalenes
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Cholesterol