Synthesis and hypolipidemic activity of diesters of arylnaphthalene lignan and their heteroaromatic analogs

Chem Pharm Bull (Tokyo). 1997 Apr;45(4):678-84. doi: 10.1248/cpb.45.678.

Abstract

A series of diesters of arylnaphthalene lignan and their heteroaromatic analogs were synthesized and evaluated for hypolipidemic activity. The disasters with modifications at C-3 showed excellent hypocholesterolemic and high-density lipoprotein (HDL) cholesterol-elevating activities. Structure-activity analysis indicated that the 2-pyridylmethyl ester 5l has the optimum activity.

MeSH terms

  • Animals
  • Cholesterol / blood
  • Cholesterol, HDL / blood
  • Hypolipidemic Agents / chemical synthesis*
  • Hypolipidemic Agents / chemistry
  • Hypolipidemic Agents / pharmacology
  • Lignans / chemical synthesis*
  • Lignans / chemistry
  • Lignans / pharmacology
  • Lipids / blood*
  • Male
  • Naphthalenes / chemical synthesis*
  • Naphthalenes / chemistry
  • Naphthalenes / pharmacology
  • Rats
  • Rats, Sprague-Dawley
  • Structure-Activity Relationship

Substances

  • Cholesterol, HDL
  • Hypolipidemic Agents
  • Lignans
  • Lipids
  • Naphthalenes
  • Cholesterol