N-Acetylprocainamide pharmacokinetics in functionally anephric patients before and after perturbation by hemodialysis

Clin Pharmacol Ther. 1979 Nov;26(5):618-28. doi: 10.1002/cpt1979265618.

Abstract

NAPA pharmacokinetics were studied in 6 functionally anephric patients. Distribution and nonrenal elimination of this drug were found to be the same as in individuals with normal renal function but renal clearance was reduced, resulting in a mean elimination t 1/2 of 41.9 hr (6.2 hr in normal subjects). Renal clearance of NAPA correlated well with ClCr. Dialysis removed NAPA from both red blood cells and plasma and increased ClT approximately fourfold. Dialysis itself resulted in a 77% reduction in ClS that limited the total amount of NAPA removed by this procedure. This reduction in ClS was sustained for at least 3 hr after dialysis and attenuated rebound in plasma NAPA concentrations.

MeSH terms

  • Acecainide / metabolism*
  • Adult
  • Computers
  • Female
  • Humans
  • Kidney Failure, Chronic / metabolism*
  • Kinetics
  • Male
  • Middle Aged
  • Models, Biological
  • Procainamide / analogs & derivatives*
  • Renal Dialysis*

Substances

  • Acecainide
  • Procainamide