Immunohistochemical demonstration of Wilms tumour gene product WT1 in a canine "neuroepithelioma" providing evidence for its classification as an extrarenal nephroblastoma

J Comp Pathol. 1997 Apr;116(3):321-7. doi: 10.1016/s0021-9975(97)80006-0.


An intradural extramedullary tumour, surgically removed from the spinal canal of a young dog with paraplegia, had the histological appearance of a nephroblastoma. Subsequent necropsy revealed no evidence of a renal primary tumour or of any other tumour. Similar tumours of the spinal canal have been described previously under a variety of names, in particular neuroepithelioma. With an antibody to the human Wilms tumour (nephroblastoma) gene product WT1, labelling of glomeruloid bodies, similar to glomerular podocytes in human fetal kidney, was demonstrated in the tumour. This finding strengthened the suggestion that it was a nephroblastoma.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • DNA-Binding Proteins / metabolism*
  • Dog Diseases / classification
  • Dog Diseases / metabolism*
  • Dogs
  • Female
  • Genes, Wilms Tumor
  • Humans
  • Immunohistochemistry
  • Kidney / metabolism
  • Kidney / pathology
  • Kidney Neoplasms / metabolism
  • Neuroectodermal Tumors, Primitive, Peripheral / classification*
  • Neuroectodermal Tumors, Primitive, Peripheral / metabolism*
  • Neuroectodermal Tumors, Primitive, Peripheral / pathology
  • Spinal Cord Neoplasms / metabolism*
  • Spinal Cord Neoplasms / pathology
  • Spinal Cord Neoplasms / veterinary*
  • Transcription Factors / metabolism*
  • WT1 Proteins
  • Wilms Tumor / metabolism
  • Wilms Tumor / veterinary*


  • DNA-Binding Proteins
  • Transcription Factors
  • WT1 Proteins