Nitric oxide synthase (NOS) in schizophrenia: increases in cerebellar vermis

Mol Chem Neuropathol. 1996 Apr;27(3):275-84. doi: 10.1007/BF02815109.


A high proportion of neurons in the cerebellum and in cholinergic brainstem nuclei stain positive for nicotinamide adenine dinucleotide phosphate-diaphorase (NADPHd), which is a nitric oxide synthase (NOS). Recent evidence suggests that schizophrenia may involve increased numbers of NADPHd-stained neurons in different areas of the subcortex. This led us to examine the actual concentration of NOS in postmortem brain specimens of cerebellum, and the relevant regions of brainstem tegmentum, to see if NOS concentrations were also increased in schizophrenia. Postmortem brain tissue was obtained at autopsy from schizophrenics and controls who did not have other brain disease. In patients with schizophrenia, NOS concentration was higher.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Aged
  • Aged, 80 and over
  • Antipsychotic Agents / therapeutic use
  • Brain Stem / enzymology
  • Cerebellum / enzymology*
  • Cerebellum / pathology
  • Female
  • Humans
  • Male
  • Middle Aged
  • NADPH Dehydrogenase / metabolism
  • Neurons / enzymology*
  • Neurons / pathology
  • Nitric Oxide Synthase / metabolism*
  • Organ Size
  • Reference Values
  • Schizophrenia / drug therapy
  • Schizophrenia / enzymology*
  • Schizophrenia / pathology
  • Tegmentum Mesencephali / enzymology
  • Tegmentum Mesencephali / pathology


  • Antipsychotic Agents
  • Nitric Oxide Synthase
  • NADPH Dehydrogenase