Fibromyalgia syndrome (FM) and nonarticular tenderness in relatives of patients with FM

J Rheumatol. 1997 May;24(5):941-4.


Objective: To determine the prevalence of fibromyalgia (FM) and to assess nonarticular tenderness in relatives of patients with FM.

Methods: Thirty female patients with FM randomly chosen from 117 of their close relatives (parents, brothers, sisters, children, husbands) were assessed for nonarticular tenderness. A count of 18 tender points was conducted by thumb palpation, and tenderness thresholds were assessed by dolorimetry at 9 tender sites. FM was diagnosed according to the 1990 American College of Rheumatology criteria.

Results: The prevalence of FM among blood relatives of patients with FM was 26%, and among their husbands 19%. FM prevalence in male relatives was 14%, and in female relatives 41%. The mean tender point counts of male and female young relatives was significantly higher than that of controls: 6.1 vs 0.2 (p < 0.01), and 4.4 vs 0.4 (p < 0.01) respectively. Similarly, adult relatives had considerably higher mean tender point counts than controls: 4.0 vs 0.04 (p < 0.01) and 10.3 vs 0.28 (p < 0.01) respectively, for males and females.

Conclusion: Relatives of patients with FM have a higher prevalence of FM and are more tender than the general population, as recently reported and shown in a healthy control group. This finding can be attributed to genetic and environmental factors.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Child
  • Family Health
  • Female
  • Fibromyalgia / epidemiology*
  • Fibromyalgia / genetics
  • Humans
  • Interpersonal Relations
  • Male
  • Middle Aged
  • Pain / epidemiology*
  • Pain / genetics
  • Pain Measurement
  • Prevalence