Bronchiolitis obliterans organizing pneumonia secondary to amiodarone: clinical, radiological and histological pattern

Monaldi Arch Chest Dis. 1997 Feb;52(1):24-6.


The most common lung tissue reaction to amiodarone toxicity is a nonspecific pulmonary chronic interstitial pneumonia. In a minority of patients diffuse alveolar damage, alveolar haemorrhage or bronchiolitis obliterans organizing pneumonia (BOOP) is encountered. We report the case of a patient with clinical, functional, radiological and histological signs of BOOP secondary to amiodarone. The condition was partially reversible after suspending drug treatment, and resolved after corticosteroid treatment without relapse after a 14 month follow-up.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Amiodarone / adverse effects*
  • Amiodarone / therapeutic use
  • Anti-Arrhythmia Agents / adverse effects*
  • Anti-Arrhythmia Agents / therapeutic use
  • Cryptogenic Organizing Pneumonia / chemically induced*
  • Cryptogenic Organizing Pneumonia / diagnosis
  • Humans
  • Lung / diagnostic imaging
  • Lung / pathology
  • Male
  • Radiography


  • Anti-Arrhythmia Agents
  • Amiodarone