Risk of hospitalization because of aseptic meningitis after measles-mumps-rubella vaccination in one- to two-year-old children: an analysis of the Vaccine Safety Datalink (VSD) Project

Pediatr Infect Dis J. 1997 May;16(5):500-3. doi: 10.1097/00006454-199705000-00009.


Objective: To assess the level of increased risk, if any, of hospitalizations for aseptic meningitis after Jeryl-Lynn mumps strain measles-mumps-rubella (MMR) vaccine in the Vaccine Safety Datalink population.

Study design: A possible increased risk of aseptic meningitis 8 to 14 days after receipt of MMR was observed in a preliminary screening analysis of automated data from the Vaccine Safety Datalink (VSD) project Year 2 analysis. To further evaluate this association a retrospective 10-year matched case-control study was undertaken in the four health maintenance organizations (HMOs) in the VSD project. Cases ascertained from a broad scan of the automated data were validated against a standard case definition. Two controls matched on age, sex, HMO and HMO membership were assigned per case.

Results: The VSD project involves the cooperative collection of automated vaccination and medical outcome data from four large HMOs that currently have 500,000 children younger than 7 years of age under surveillance. Review of automated screening results from the first 2 years of data revealed a possible increased risk of aseptic meningitis 0 to 14 days after MMR with a relative risk of 3.61 (95% confidence interval, 1.0 to 13.1) although the total number of cases was small. Although the automated data had suggested a possible association of aseptic meningitis with MMR containing the Jeryl-Lynn strain of mumps, review of validated hospitalized cases during the observation period did not reveal evidence of an increased risk of aseptic meningitis after MMR containing the Jeryl-Lynn strain of mumps (odds ratio < 1.0 for all analyses).

Conclusion: Although it is recognized that hospitalized cases represent a minority of the total cases of aseptic meningitis, it is reassuring that in this evaluation no increased risk of aseptic meningitis after MMR vaccine was found.

Publication types

  • Multicenter Study

MeSH terms

  • Case-Control Studies
  • Child, Preschool
  • Confidence Intervals
  • Female
  • Health Maintenance Organizations
  • Hospitalization / statistics & numerical data*
  • Humans
  • Incidence
  • Infant
  • Male
  • Measles Vaccine / adverse effects*
  • Measles-Mumps-Rubella Vaccine
  • Meningitis, Aseptic / epidemiology*
  • Meningitis, Aseptic / etiology*
  • Mumps Vaccine / adverse effects*
  • Registries
  • Retrospective Studies
  • Risk Factors
  • Rubella Vaccine / adverse effects*
  • Statistics as Topic
  • United States / epidemiology
  • Vaccines, Combined / adverse effects


  • Measles Vaccine
  • Measles-Mumps-Rubella Vaccine
  • Mumps Vaccine
  • Rubella Vaccine
  • Vaccines, Combined