The influence of ifosfamide scheduling on acute nephrotoxicity in children

Br J Cancer. 1997;75(9):1356-9. doi: 10.1038/bjc.1997.229.

Abstract

Nephrotoxicity is a significant problem in children after treatment with ifosfamide. Acute changes in renal function were compared in 16 children receiving 9 g m(-2) of ifosfamide as a 72-h continuous infusion on one occasion and, on another course, divided into three 1-h infusions on consecutive days. Subclinical acute nephrotoxicity was demonstrated with both schedules, but there were no significant differences in severity.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Antineoplastic Agents, Alkylating / administration & dosage
  • Antineoplastic Agents, Alkylating / therapeutic use*
  • Child
  • Child, Preschool
  • Creatinine / blood
  • Drug Administration Schedule
  • Female
  • Humans
  • Ifosfamide / administration & dosage
  • Ifosfamide / therapeutic use*
  • Infant
  • Infusions, Intravenous
  • Kidney / drug effects*
  • Kidney / pathology
  • Kidney / physiopathology
  • Kidney Function Tests
  • Male
  • Neoplasms / drug therapy
  • Urinalysis

Substances

  • Antineoplastic Agents, Alkylating
  • Creatinine
  • Ifosfamide