Cyclin D1 in mammary carcinoma

J Pathol. 1997 Mar;181(3):267-9. doi: 10.1002/(SICI)1096-9896(199703)181:3<267::AID-PATH783>3.0.CO;2-X.

Abstract

The control of the cell-cycle-associated protein cyclin D1 and its variable behaviour in normal and transformed cells is described and contrasted with its activity in vivo. The role of cyclin D1 as a prognostic and predictive marker is examined in clinical breast cancer. High levels of the protein are seen in well differentiated, oestrogen receptor positive tumours, which respond well to tamoxifen treatment for metastatic disease.

Publication types

  • Review

MeSH terms

  • Animals
  • Antineoplastic Agents, Hormonal / therapeutic use
  • Biomarkers, Tumor / metabolism*
  • Breast Neoplasms / drug therapy
  • Breast Neoplasms / metabolism*
  • Cyclin D1
  • Cyclins / metabolism*
  • Female
  • Humans
  • Mice
  • Neoplasm Proteins / metabolism*
  • Oncogene Proteins / metabolism*
  • Prognosis
  • Tamoxifen / therapeutic use
  • Treatment Outcome

Substances

  • Antineoplastic Agents, Hormonal
  • Biomarkers, Tumor
  • Cyclins
  • Neoplasm Proteins
  • Oncogene Proteins
  • Tamoxifen
  • Cyclin D1