Cyclic peptides from higher plants. 34. Segetalins G and H, structures and estrogen-like activity of cyclic pentapeptides from Vaccaria segetalis

Y S Yun; H Morita; K Takeya; H Itokawa

doi:10.1021/np960617n

Cyclic peptides from higher plants. 34. Segetalins G and H, structures and estrogen-like activity of cyclic pentapeptides from Vaccaria segetalis

J Nat Prod. 1997 Mar;60(3):216-8. doi: 10.1021/np960617n.

Authors

Y S Yun¹, H Morita, K Takeya, H Itokawa

Affiliation

¹ Department of Pharmacognosy, Tokyo University of Pharmacy and Life Science, Japan.

PMID: 9157189
DOI: 10.1021/np960617n

Abstract

Segetalins G and H (1-2) possessing estrogen-like activity are cyclic pentapeptides from the seeds of Vaccaria segetalis. Their structures, cyclo(-Gly-Ala-Lys-Tyr-Val) (1) and cyclo(-Gly-Phe-Ser-Tyr-Arg-) (2), were determined by interpretation of spectral data.

MeSH terms

Animals
Estrogens / isolation & purification*
Estrogens / pharmacology
Female
Magnetic Resonance Spectroscopy
Molecular Conformation
Ovariectomy
Peptides, Cyclic / isolation & purification*
Peptides, Cyclic / pharmacology
Protein Conformation
Rats
Rats, Sprague-Dawley
Seeds / chemistry*
Uterus / drug effects
Uterus / growth & development

Substances

Estrogens
Peptides, Cyclic
segetalin G
segetalin H