Metoclopramide metabolism and determination by high-pressure liquid chromatography

J Pharm Sci. 1977 Nov;66(11):1615-8. doi: 10.1002/jps.2600661128.

Abstract

A high-pressure liquid chromatographic method suitable for determining plasma metoclopramide levels at normal (10-20 mg) doses is described. Eight metabolites as well as metclopramide were isolated and identified in rat, dog. and human urine. The only common metabolite in these species is 2-[(4-amino-5-chloro-2-methoxybenzoyl)-amino] acetic acid. N-Deethylation is a major pathway for metoclopramide metabolism in the lower animals but not in humans. Metoclopramide is excreted mainly unchanged or as its conjugates by humans.

MeSH terms

  • Animals
  • Biotransformation
  • Chromatography, High Pressure Liquid
  • Chromatography, Thin Layer
  • Dogs
  • Female
  • Humans
  • Male
  • Mass Spectrometry
  • Metoclopramide / metabolism*
  • Rats

Substances

  • Metoclopramide