The Convergence of Murein Recycling Research With Beta-Lactamase Research

Microb Drug Resist. Spring 1996;2(1):105-12. doi: 10.1089/mdr.1996.2.105.


The story of how investigation of Escherichia coli cell wall elongation evolved into a study of murein recycling and how this led to the discovery that ampG and ampD were required for both murein recycling and beta-lactamase regulation is chronicled. Preliminary information on two other genes believed to be involved in recycling, nagZ, the structural gene for beta-N-acetylglucosaminidase, and tpl, the presumed structural gene for the hypothetical tripeptide-adding enzyme, is presented. The possibility that recycling of murein fragments serves a signaling function is discussed.

Publication types

  • Review

MeSH terms

  • Escherichia coli / enzymology
  • Escherichia coli / genetics
  • Escherichia coli / metabolism*
  • Peptidoglycan / biosynthesis
  • Peptidoglycan / genetics
  • Peptidoglycan / metabolism*
  • beta-Lactamases / biosynthesis
  • beta-Lactamases / genetics
  • beta-Lactamases / metabolism*


  • Peptidoglycan
  • beta-Lactamases