Nuclear organization and gene expression: homologous pairing and long-range interactions

Curr Opin Cell Biol. 1997 Jun;9(3):388-95. doi: 10.1016/s0955-0674(97)80012-9.


Genetic studies have demonstrated that pairing interactions between homologous chromosomes and long-range associations between nonhomologous sites can influence gene expression. Recent work has revealed that such influences are widespread in eukaryotes and that chromosome architecture is likely to be of fundamental importance for nuclear structure and function.

Publication types

  • Review

MeSH terms

  • Alleles
  • Animals
  • Cell Nucleus / ultrastructure*
  • Chromosomes / physiology*
  • Drosophila melanogaster / genetics
  • Gene Expression Regulation*
  • Heterochromatin / physiology
  • Heterozygote
  • Recombination, Genetic
  • Saccharomyces cerevisiae
  • Sequence Homology, Amino Acid
  • Structure-Activity Relationship
  • Transcriptional Activation
  • Transgenes


  • Heterochromatin