RNA polymerase II holoenzyme and transcriptional regulation

Curr Opin Cell Biol. 1997 Jun;9(3):310-9. doi: 10.1016/s0955-0674(97)80002-6.


RNA polymerase II holoenzymes isolated from yeast and mammalian cells are large, preassembled complexes that contain some or all of the general transcription initiation factors and many other polypeptides. Recent experiments suggest that these holoenzymes may mediate alterations in chromatin structure and play a key role in regulatory mechanisms that influence transcriptional initiation, RNA chain elongation, RNA processing and transcription termination.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Chromatin / physiology
  • Chromatin / ultrastructure
  • DNA-Binding Proteins / physiology
  • Gene Expression Regulation*
  • Macromolecular Substances
  • Promoter Regions, Genetic
  • RNA Polymerase II / chemistry
  • RNA Polymerase II / physiology*
  • Repressor Proteins / physiology
  • Saccharomyces cerevisiae
  • Transcription Factors / chemistry
  • Transcription Factors / physiology*
  • Transcription, Genetic*


  • Chromatin
  • DNA-Binding Proteins
  • Macromolecular Substances
  • Repressor Proteins
  • Transcription Factors
  • RNA Polymerase II