Protein functions in pre-mRNA splicing

Curr Opin Cell Biol. 1997 Jun;9(3):320-8. doi: 10.1016/s0955-0674(97)80003-8.


Proteins have been implicated in an expanding variety of functions during pre-mRNA splicing. Molecular cloning has identified genes encoding spliceosomal proteins that potentially act as novel RNA helicases, GTPases, or protein isomerases. Novel protein-protein and protein-RNA interactions that are required for functional spliceosome formation have also been described. Finally, growing evidence suggests that proteins may contribute directly to the spliceosome's active sites.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Fungal Proteins / metabolism
  • Macromolecular Substances
  • Protein Binding
  • RNA Precursors / metabolism*
  • RNA Splicing*
  • RNA, Fungal / metabolism
  • RNA, Messenger / metabolism
  • Ribonucleoproteins / physiology
  • Ribonucleoproteins, Small Nuclear / physiology*
  • Saccharomyces cerevisiae
  • Spliceosomes / physiology*


  • Fungal Proteins
  • Macromolecular Substances
  • RNA Precursors
  • RNA, Fungal
  • RNA, Messenger
  • Ribonucleoproteins
  • Ribonucleoproteins, Small Nuclear