Antibodies against bacterial lipopolysaccharides in Japanese patients with ankylosing spondylitis

Br J Rheumatol. 1997 Apr;36(4):491-3. doi: 10.1093/rheumatology/36.4.491.


We investigated IgG, IgA and IgM class specific antibodies to five bacterial (Klebsiella pneumoniae, Escherichia coli, Salmonella enteritidis, Salmonella typhimurium and Shigella flexneri) lipopolysaccharides (LPS) by enzyme-linked immunosorbent assay in 144 Japanese patients with ankylosing spondylitis (AS). AS patients had significantly elevated IgA antibodies to K. pneumoniae LPS, Salmonella enteritidis LPS and Salmonella typhimurium LPS; however, there was no correlation between antibody level to LPS and acute-phase reactants, erythrocyte sedimentation rate and serum C-reactive protein.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antibodies, Bacterial / blood*
  • Blood Sedimentation
  • C-Reactive Protein / analysis
  • Enterobacteriaceae / immunology*
  • Enzyme-Linked Immunosorbent Assay
  • Escherichia coli / immunology
  • Humans
  • Japan
  • Klebsiella pneumoniae / immunology
  • Lipopolysaccharides / immunology*
  • Salmonella enteritidis / immunology
  • Salmonella typhimurium / immunology
  • Shigella flexneri / immunology
  • Spondylitis, Ankylosing / immunology*


  • Antibodies, Bacterial
  • Lipopolysaccharides
  • C-Reactive Protein