Chinese herbs and warfarin potentiation by 'danshen'

J Intern Med. 1997 Apr;241(4):337-9. doi: 10.1046/j.1365-2796.1997.134137000.x.


Drug interactions with warfarin can be dangerous and although common drug interactions are now well recognized those with Chinese herbs are not widely appreciated. 'Danshen' is a herbal medicine often used for various complaints, particularly cardiovascular, in the Chinese community. We report a case of danshen-induced overcoagulation with severe and dangerous abnormalities of clotting in a patient with rheumatic heart disease.

Publication types

  • Case Reports

MeSH terms

  • Anticoagulants / adverse effects*
  • Anticoagulants / therapeutic use
  • Blood Coagulation Tests
  • Drug Combinations
  • Drug Synergism
  • Drugs, Chinese Herbal / adverse effects*
  • Drugs, Chinese Herbal / therapeutic use
  • Female
  • Humans
  • Middle Aged
  • Phenanthrolines / adverse effects*
  • Phenanthrolines / therapeutic use
  • Plant Extracts*
  • Warfarin / adverse effects*
  • Warfarin / therapeutic use


  • Anticoagulants
  • Drug Combinations
  • Drugs, Chinese Herbal
  • Phenanthrolines
  • Plant Extracts
  • Warfarin
  • dan-shen root extract