The Helicobacter pylori seroprevalence in blood donors related to Lewis (a,b) histo-blood group phenotype

Eur J Gastroenterol Hepatol. 1997 Apr;9(4):367-70. doi: 10.1097/00042737-199704000-00009.


Objective: To study a possible association of the Helicobacter pylori seroprevalence with ABO(H) and Lewis (a,b) blood group phenotypes in blood donors.

Design: A cross-sectional study of blood donors using ABO(H) and Lewis (a,b) blood group phenotype as predictors.

Methods: ABO(H) and Lewis (a,b) blood group phenotyping was performed with monoclonal antibody. The H. pylori immunoglobulin G (IgG) antibody relative activity was evaluated by enzyme-linked immunosorbent assay (ELISA) using acid glycine extract from H. pylori.

Subjects: One hundred and fifty-nine randomly selected blood transfusion donors.

Results: The individuals with Lewis (a+b-)/non-secretor phenotype showed a significantly higher proportion of the H. pylori-seronegative subjects and a lower IgG immune response to H. pylori antigens as compared with the individuals of Lewis (a-b+)/secretor phenotype.

Conclusion: The Lewis (a,b) histo-blood group antigens are implicated in the mechanisms of naturally occurring resistance to H. pylori infection.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • ABO Blood-Group System / immunology*
  • Adolescent
  • Adult
  • Antibodies, Bacterial / analysis*
  • Antibodies, Monoclonal
  • Antigens, Bacterial / immunology
  • Antigens, Surface / immunology
  • Blood Donors*
  • Cross-Sectional Studies
  • Enzyme-Linked Immunosorbent Assay
  • Estonia / epidemiology
  • Female
  • Helicobacter Infections / blood*
  • Helicobacter pylori / immunology*
  • Humans
  • Immunophenotyping
  • Lewis Blood Group Antigens / immunology*
  • Male
  • Middle Aged
  • Prevalence
  • Random Allocation
  • Secretory Component / immunology


  • ABO Blood-Group System
  • Antibodies, Bacterial
  • Antibodies, Monoclonal
  • Antigens, Bacterial
  • Antigens, Surface
  • Lewis Blood Group Antigens
  • Secretory Component