Apoptosis as a proinflammatory event: what can we learn from bacteria-induced cell death?

Trends Microbiol. 1997 May;5(5):201-4. doi: 10.1016/S0966-842X(97)01044-5.


Infection of cells by some pathogenic bacteria triggers host cell apoptosis. Bacteria-induced apoptosis appears to promote an inflammatory response that causes tissue damage and further bacterial colonization. Shigella pathogenesis offers a paradigm for the role of apoptosis in bacterial infections.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Apoptosis / immunology*
  • Bacterial Infections / immunology
  • Dysentery, Bacillary / epidemiology
  • Dysentery, Bacillary / immunology*
  • Humans
  • Inflammation / physiopathology*
  • Macrophages