Differences in aldehyde oxidase activity in cytosolic preparations of human and monkey liver

Biochem Mol Biol Int. 1997 May;41(6):1153-60. doi: 10.1080/15216549700202241.


This study presents data showing individual differences in aldehyde oxidase activity in human and monkey liver cytosols. When assayed with benzaldehyde as a substrate, a significant inter-subject variation in the activity was found in the human liver preparations. When assayed with N1-methylnicotinamide as a substrate, the inter-subject variation of the activity was also observed, but to a lesser extent compared with that of the activity with benzaldehyde. Similarly, variations in aldehyde oxidase activity were found in the monkey liver preparations when assayed with benzaldehyde or N1-methylnicotinamide. The present study suggested that at least two isozymes of aldehyde oxidase exist in the human liver preparations.

Publication types

  • Comparative Study

MeSH terms

  • Aged
  • Aldehyde Oxidase
  • Aldehyde Oxidoreductases / chemistry*
  • Aldehyde Oxidoreductases / metabolism
  • Animals
  • Benzaldehydes / metabolism
  • Blotting, Western
  • Cytosol / enzymology*
  • Female
  • Humans
  • Isoenzymes / chemistry
  • Isoenzymes / metabolism
  • Liver / chemistry
  • Liver / cytology
  • Liver / enzymology*
  • Macaca mulatta
  • Male
  • Middle Aged
  • Niacinamide / analogs & derivatives
  • Niacinamide / metabolism


  • Benzaldehydes
  • Isoenzymes
  • Niacinamide
  • Aldehyde Oxidoreductases
  • Aldehyde Oxidase
  • benzaldehyde
  • N-methylnicotinamide