The risk factor profile of recto-sigmoid adenomas: a prospective screening study of 665 patients in a clinical rehabilitation centre

Eur J Cancer Prev. 1997 Feb;6(1):38-43. doi: 10.1097/00008469-199702000-00007.


During a prospective screening study for recto-sigmoid adenomatous polyps, the influence of the following risk factors was evaluated: age; gender; body mass index; heredity for colorectal malignancy; diabetes; hypertension; constipation; previous gastric surgery; previous gastric acid inhibition; alcohol and cigarette consumption; serum cholesterol; serum triglycerides; and serum gastrin. Screening fibre-sigmoidoscopy of 665 patients (aged between 50 and 60 years) at a clinical rehabilitation centre for gastrointestinal and metabolic diseases showed that 146 had one or several adenomas. The study population was overweight by a mean of about 15%. Comparison of those with and those without adenoma using univariate analysis, showed that the group with adenomas had higher serum triglyceride values, drank more alcohol on a regular or excessive basis, were more frequent smokers, and had a tendency to raised fasting serum glucose. In a multivariate analysis, age, high serum triglycerides and high alcohol consumption were risk factors for recto-sigmoid adenomas. The risk factor profile identified in this study may help in the selection of individuals for screening sigmoidoscopy from a similar background population. It also identifies target conditions for primary prevention of colorectal neoplasia.

Publication types

  • Clinical Trial

MeSH terms

  • Adenoma / blood
  • Adenoma / epidemiology
  • Adenoma / prevention & control*
  • Age Distribution
  • Alcoholism / complications
  • Analysis of Variance
  • Female
  • Germany / epidemiology
  • Humans
  • Logistic Models
  • Male
  • Mass Screening* / methods
  • Middle Aged
  • Multivariate Analysis
  • Obesity / complications
  • Prospective Studies
  • Rectal Neoplasms / blood
  • Rectal Neoplasms / epidemiology
  • Rectal Neoplasms / prevention & control*
  • Rehabilitation Centers
  • Risk Factors
  • Sex Distribution
  • Sigmoid Neoplasms / blood
  • Sigmoid Neoplasms / epidemiology
  • Sigmoid Neoplasms / prevention & control*
  • Sigmoidoscopy
  • Smoking / adverse effects
  • Triglycerides / blood


  • Triglycerides