[Changes in the blood circulation in the middle cerebral and common carotid arteries of rats under the influence of flunarizine]

Abstract

Experiments conducted on Wistar rats under general anesthesia using the Doppler ultrasonic method showed that flunarizine caused a slowly developing (for 20 min), moderate (25%), and prolonged (90 min) increase of the blood flow in the middle cerebral artery. In the common carotid artery the drug induced two-phase changes in blood circulation. The initial increase in the blood flow was replaced by its reduction below the basic level.