Transposable Elements: How non-LTR Retrotransposons Do It

Curr Biol. 1997 Apr 1;7(4):R245-8. doi: 10.1016/s0960-9822(06)00112-6.

Abstract

The source of the enzyme activity responsible for the transposition of retrotransposons of the type that lack terminal repeats has at last been identified: in L1Hs elements, it is encoded by the second open reading frame and is a nuclease related to the apurinic repair endonucleases.

Publication types

  • Review

MeSH terms

  • Animals
  • DNA Repair / genetics
  • DNA-(Apurinic or Apyrimidinic Site) Lyase
  • Deoxyribonuclease IV (Phage T4-Induced)
  • Drosophila melanogaster / genetics
  • Drosophila melanogaster / virology
  • Genes, gag
  • Genes, pol
  • Humans
  • Lyases / metabolism
  • Models, Genetic
  • Moloney murine leukemia virus / genetics
  • Open Reading Frames
  • RNA-Directed DNA Polymerase / metabolism
  • Repetitive Sequences, Nucleic Acid*
  • Retroelements*
  • Retroviridae / genetics*
  • Saccharomyces cerevisiae / genetics
  • Saccharomyces cerevisiae / virology
  • Sequence Deletion

Substances

  • Retroelements
  • RNA-Directed DNA Polymerase
  • Deoxyribonuclease IV (Phage T4-Induced)
  • Lyases
  • DNA-(Apurinic or Apyrimidinic Site) Lyase